89-7748-41 Recombinant Human PARM1/PARM-1 Protein (His Tag) 100ug PKSH030552
[Elabscience]
特徴
- 背景：Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50% of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11%. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：AAH13294.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser258
- 遺伝子構造：A DNA sequence encoding the human PARM1 (AAH13294.1) (Met1-Ser258) was expressed with a polyhistidine tag at the C-terminus.
- 別名（遺伝子名）：Cipar1;DKFZP564O0823;PARM-1;WSC4
- 分子量：25.7 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37314-Elabscience-PKSH030552.pdf
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89-7748-41
Recombinant Human PARM1/PARM-1 Protein (His Tag) 100ug
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89-7748-40
Recombinant Human PARM1/PARM-1 Protein (His Tag) 20ug
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