89-7747-91 ［取扱停止］Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag) 10ug PKSH030523
[Elabscience]
特徴
- 背景：Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness; and several of its transcriptional regulators; which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a negative regulator of Tspan8 expression. p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment. Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis. TSPAN8 may play an important role in mCRC cell invasion. TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal. TSPAN8 overexpression promoted cell proliferation and invasion; while TSPAN8 suppression inhibited cell proliferation and invasion. TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells; and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：(87.8+10.7) % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P19075
- タグ種類：N-His
- アミノ酸配列：Lys110-Asn205
- 遺伝子構造：A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.
- 別名（遺伝子名）：CO-029;TM4SF3
- 分子量：13.4 kDa
- 組成：Lyophilized from sterile PBS; pH 7.4.
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37294-Elabscience-PKSH030523.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7747-92
Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag) 20ug
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89-7747-91
Recombinant Human TSPAN8/Tetraspanin 8 Protein (His Tag) 10ug
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