89-7746-91 ［取扱停止］Recombinant Human LAIR1 Protein (Fc Tag) 200ug PKSH030465
[Elabscience]
特徴
- 背景：Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.
仕様
- サイズ：200ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：>(86.1+10.4) % as determined by reducing SDS-PAGE..
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q6GTX8.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Tyr165
- 遺伝子構造：A DNA sequence encoding the human LAIR1 (Q6GTX8.1) (Met1-Tyr165) was expressed with the Fc region of human IgG1 at the C-terminus.
- 別名（遺伝子名）：Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1
- 分子量：42.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37251-Elabscience-PKSH030465.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7746-90
Recombinant Human LAIR1 Protein (Fc Tag) 50ug
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89-7746-91
Recombinant Human LAIR1 Protein (Fc Tag) 200ug
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