89-7746-80 ［取扱停止］Recombinant Human CSF2RA/GM-CSFR Protein (Fc Tag)(Active) 50ug PKSH030459
[Elabscience]
特徴
- 背景：CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_006131.2
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Gly 320
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Gly 320) of human GM-CSFRα (NP_006131.2) pro-protein was expressed with the C-terminal fused Fc region of human IgG1.
- 活性：Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 10-15 μg/ml.
- 別名（遺伝子名）：Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha; GM-CSF-R-Alpha; GMCSFR-Alpha; GMR-Alpha; CDw116; CD116; CSF2RA; CSF2R; CSF2RY
- 分子量：61.2 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105380-Elabscience-PKSH030459.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7746-80
Recombinant Human CSF2RA/GM-CSFR Protein (Fc Tag)(Active) 50ug
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89-7746-81
Recombinant Human CSF2RA/GM-CSFR Protein (Fc Tag)(Active) 100ug
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