89-7746-76 ［取扱停止］Recombinant Human ACE2 Protein (Fc Tag)(Active) 10ug PKSH030457
[Elabscience]
特徴
- 背景：Angiotensin-converting enzyme 2 (ACE2); a first homolog of ACE; regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular; renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme; an homolog of ACE; hydrolyzes angiotensin (Ang) I to produce Ang-(1-9); which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus; the major biologically active product of ACE2 is Ang-(1-7); which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension; cardiac function; heart function and diabetes; and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS); ACE; AngII; and AT1R promote the disease pathogenesis; whereas ACE2 and the AT2R protect from ARDS. Importantly; ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore; the recent explosion of research into the ACE2 homolog; collectrin; has revealed a new physiological function of ACE2 as an amino acid transporter; which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.
仕様
- サイズ：10ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_068576.1
- タグ種類：C-Fc
- アミノ酸配列：Met 1-Ser 740
- 遺伝子構造：A DNA sequence encoding the extracellular domain (Met 1-Ser 740) of human ACE2 precursor (NP_068576.1) was expressed with the fused Fc region of human IgG1 at the C-terminus.
- 活性：1.Using the Octet RED System; the affinity constant (Kd) of human AEC2-Fc bound to Spike (HCoV-EMC/2012) was 6 nM.2. Using the Octet RED System; the affinity constant (Kd) of human AEC2-Fc bound to Spike (HCoV-EMC/2012) was 30 nM.3. Using the Octet RED System; the affinity constant (Kd) of human AEC2-Fc bound to Spike (HCoV-EMC/2012) (ECD; aa 1-1297) was 30 nM.4. Using the Octet RED System; the affinity constant (Kd) of human AEC2-Fc bound to Spike-His (aa 1-760) was 10 nM.
- 別名（遺伝子名）：Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
- 分子量：110.3 kDa
- 組成：Lyophilized from sterile 100mM Glycine; 10mM NaCl; 50mM Tris; pH 7.5
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37244-Elabscience-PKSH030457.pdf
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89-7746-76
Recombinant Human ACE2 Protein (Fc Tag)(Active) 10ug
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89-7746-77
Recombinant Human ACE2 Protein (Fc Tag)(Active) 20ug
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