89-7746-70 ［取扱停止］Recombinant Human Periostin/OSF-2 Protein (His Tag)(Active) 50ug PKSH030453
[Elabscience]
特徴
- 背景：Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：HEK293 Cells
- 純度：> 97 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001129407.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Gln 781
- 遺伝子構造：A DNA sequence encoding the human POSTN isoform 3 (NP_001129407.1) corresponding to amino acid (Met 1-Gln 781) was expressed with a C-terminal polyhistidine tag.
- 活性：Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells.When cells are added to POSTN-His coated plates (10μg/mL, 100μL/well), approximately >60% will adhere specifically after 30 minutes at 37℃.
- 別名（遺伝子名）：Osteoblast-specific factor 2;OSF-2;POSTN; Periostin;PDLPOSTN;periostin;PN
- 分子量：86 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37241-Elabscience-PKSH030453.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7746-70
Recombinant Human Periostin/OSF-2 Protein (His Tag)(Active) 50ug
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89-7746-71
Recombinant Human Periostin/OSF-2 Protein (His Tag)(Active) 100ug
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