89-7746-52 ［取扱停止］Recombinant Human IFNA4 Protein (His Tag)(Active) 20ug PKSH030443
[Elabscience]
特徴
- 背景：Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Yeast
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_066546.1
- タグ種類：C-His
- アミノ酸配列：Cys24-Asp189
- 遺伝子構造：A DNA sequence encoding the human IFNA4 (NP_066546.1) (Cys24-Asp189) was expressed with a polyhistidine tag at the C-terminus.
- 活性：Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus.The ED50 for this effect is 2-10pg/mL.
- 別名（遺伝子名）：Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76;Interferon alpha-M1;IFNA4
- 分子量：20.8 kDa
- 組成：Lyophilized from sterile PBS, pH 7.4
- 保存条件：Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105377-Elabscience-PKSH030443.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7746-53
Recombinant Human IFNA4 Protein (His Tag)(Active) 100ug
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89-7746-52
Recombinant Human IFNA4 Protein (His Tag)(Active) 20ug
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