89-7746-32 Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active) 50ug PKSH030428
[Elabscience]
特徴
- 背景：As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：NP_005219
- タグ種類：N-His-GST
- アミノ酸配列：Met 668-Ala 1210
- 遺伝子構造：A DNA sequence encoding the cytoplasmic domain (Met 668-Ala 1210) of human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
- 別名（遺伝子名）：ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
- 分子量：89.1 kDa
- 組成：Supplied as sterile 20 mM Tris; 500 mM NaCl; 10 % glycerol; pH 7.4
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37227-Elabscience-PKSH030428.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7746-31
Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active) 20ug
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89-7746-32
Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active) 50ug
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