89-7746-10 Recombinant Human PTP1B/PTPN1 Protein (His Tag)(Active) 100ug PKSH030416
[Elabscience]
特徴
- 背景：PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.
仕様
- サイズ：100ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_002818.1
- タグ種類：N-His
- アミノ酸配列：Glu 2-Asn 321
- 遺伝子構造：A DNA sequence encoding the human PTPN1 (NP_002818.1) (Glu 2-Asn 321) was expressed, with a polyhistide tag at the N-terminus.
- 活性：Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor (aa988-998) phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/μg.
- 別名（遺伝子名）：PTP1B;PTPN1
- 分子量：38 kDa
- 組成：Supplied as sterile 10 mM Hepes, 150 mM NaCl, 1 mM DTT, pH 7.5
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37218-Elabscience-PKSH030416.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
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89-7746-09
Recombinant Human PTP1B/PTPN1 Protein (His Tag)(Active) 50ug
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89-7746-10
Recombinant Human PTP1B/PTPN1 Protein (His Tag)(Active) 100ug
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