89-7746-06 Recombinant Human MKK6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)(Active) 50ug PKSH030414
[Elabscience]
特徴
- 背景：Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein kinase superfamily; STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 88 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P52564-1
- タグ種類：N-His & GST
- アミノ酸配列：Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp
- 遺伝子構造：A DNA sequence encoding the human MAP2K6 isoform 1 (P52564-1) (Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：The specific activity was determined to be 1250 nmol/min/mg using inactive MAPK14 as substrate.
- 別名（遺伝子名）：MAPKK6;MEK6;MKK6;PRKMK6;SAPKK-3;SAPKK3;MAP2K6
- 分子量：65.3 kDa
- 組成：Supplied as sterile 20mM Tris; 500mM NaCl; pH 8.0; 10% glycerol
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37216-Elabscience-PKSH030414.pdf
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