89-7746-01 ［取扱停止］Recombinant Human BMPR1B/ALK-6 Protein (aa 149-502, His&GST Tag) 20ug PKSH030412
[Elabscience]
特徴
- 背景：BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 90 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001194.1
- タグ種類：N-His & GST
- アミノ酸配列：Arg 149-Leu 502
- 遺伝子構造：A DNA sequence encoding the human ALK6 (NP_001194.1) cytoplasmic domain (Arg 149-Leu 502) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 別名（遺伝子名）：ALK-6;ALK6;CDw293
- 分子量：68.3 kDa
- 組成：Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.5, 20% gly, 0.3mM DTT
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105367-Elabscience-PKSH030412.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7746-01
Recombinant Human BMPR1B/ALK-6 Protein (aa 149-502, His&GST Tag) 20ug
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89-7746-02
Recombinant Human BMPR1B/ALK-6 Protein (aa 149-502, His&GST Tag) 50ug
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