89-7745-91 Recombinant Human Bruton Tyrosine Kinase/BTK Kinase Protein (His Tag)(Active) 50ug PKSH030407
[Elabscience]
特徴
- 背景：Bruton's tyrosine kinase (or BTK) is a type of kinase protein expressed in B lymphocytes and T cells. BTK contains a PH domain which binds phosphatidylinositol(3,4,5)-trisphosphate (PIP3). After binding to PIP3, BTK is induced to phosphorylate phospholipase C, which in turn hydrolyzes PIP2 into two second messagers, IP3 and DAG, which then modulate the activity of downstream proteins during B-cell signaling. Btk is also found implicated in the primary immunodeficiency disease X-linked agammaglobulinemia(Bruton's agammaglobulinemia). BTK played a key role in B-cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with X-linked agammaglobulinemia have normal pre-B cell populations in their bone marrow but these B-cells can not mature and enter the circulation.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_000052.1
- タグ種類：C-His
- アミノ酸配列：Met 1-Ser 659
- 遺伝子構造：A DNA sequence encoding the human BTK (NP_000052.1) (Met 1-Ser 659) was expressed with a C-terminal polyhistidine tag.
- 活性：1. The specific activity was determined to be 115 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.2. Measured by its ability to bind human BLNK in a functional ELISA.
- 別名（遺伝子名）：AGMX1;AT;ATK;BPK;IMD1;PSCTK1;XLA
- 分子量：77.8 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.0
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37212-Elabscience-PKSH030407.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7745-90
Recombinant Human Bruton Tyrosine Kinase/BTK Kinase Protein (His Tag)(Active) 20ug
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89-7745-91
Recombinant Human Bruton Tyrosine Kinase/BTK Kinase Protein (His Tag)(Active) 50ug
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