89-7745-52 Recombinant Human DAPK3/ZIPK Protein (GST Tag)(Active) 50ug PKSH030384
[Elabscience]
特徴
- 背景：Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains one protein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 / ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 85 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：NP_001339.1
- タグ種類：N-GST
- アミノ酸配列：Met 1-Arg 454
- 遺伝子構造：A DNA sequence encoding the full length of human DAPK3 (NP_001339.1) (Met 1-Arg 454) was fused with the GST tag at the N-terminus.
- 活性：The specific activity was determined to be 5 nmol/min/mg using MBP as substrate.
- 別名（遺伝子名）：DLK;ZIP;ZIPK
- 分子量：79 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, 10mM GSH, pH 7.4
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37197-Elabscience-PKSH030384.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7745-52
Recombinant Human DAPK3/ZIPK Protein (GST Tag)(Active) 50ug
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89-7745-51
Recombinant Human DAPK3/ZIPK Protein (GST Tag)(Active) 20ug
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