89-7745-37 ［取扱停止］Recombinant Human RSK3/RPS6KA2 Protein (GST Tag)(Active) 20ug PKSH030377
[Elabscience]
特徴
- 背景：Ribosomal protein S6 kinase alpha-2, also known as 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest, increased apoptosis, reduced levels of phosphorylated extracellular signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 / RSK-3 contains one AGC-kinase C-terminal domain and two protein kinase domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It transiently dissociates following mitogenic stimulation. RPS6KA2 / RSK-3 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 84 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：Q15349-1
- タグ種類：N-GST
- アミノ酸配列：Met 1-Leu 733
- 遺伝子構造：A DNA sequence encoding the human RPS6KA2 isoform 1 (Q15349-1) (Met 1-Leu 733) was fused with the GST tag at the N-terminus.
- 活性：The specific activity was determined to be 41 nmol/min/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate.
- 別名（遺伝子名）：HU-2;MAPKAPK1C;p90-RSK3;pp90RSK3;RSK;RSK3;S6K-alpha;S6K-alpha2
- 分子量：110 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.0, 20mM GSH
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37191-Elabscience-PKSH030377.pdf
- この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL：06-6447-8641
- FAX：06-6447-8642
- E-mail：[email protected]
商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
|
89-7745-38
Recombinant Human RSK3/RPS6KA2 Protein (GST Tag)(Active) 50ug
|
|
|
89-7745-37
Recombinant Human RSK3/RPS6KA2 Protein (GST Tag)(Active) 20ug
|
よくあるご質問（FAQ）
掲載カタログ情報
| 掲載カタログ名 | 掲載ページ |
|---|