89-7745-20 ［取扱停止］Recombinant Human PAK3 Protein (His Tag)(Active) 20ug PKSH030366
[Elabscience]
特徴
- 背景：PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group I p21-activated kinases (PAK1/2/3) is demonstrated as ERK3/ERK4 activation loop kinases. It has been shown that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response. Besides regulation enzymatic activation of ERK3/ERK4, PAKs can also play roles in downstream activation of MAP kinase-activated protein kinase 5 (MK5) in vivo. Thus, the group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3/ERK4-MK5 signaling pathway. In clinical, PAK has been proposed as a potential therapeutic target in schwannomas.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 80 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O75914-2
- タグ種類：C-His
- アミノ酸配列：Met 1-Arg 544
- 遺伝子構造：A DNA sequence encoding the human PAK3 isoform 2 (O75914-2) (Met 1-Arg 544) was fused with a polyhistidine tag at the C-terminus.
- 活性：The specific activity was determined to be 98 nmol/min/mg using MBP as substrate.
- 別名（遺伝子名）：bPAK;CDKN1A;hPAK3;MRX30;MRX47;OPHN3;PAK3beta
- 分子量：62 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105351-Elabscience-PKSH030366.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7745-20
Recombinant Human PAK3 Protein (His Tag)(Active) 20ug
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89-7745-21
Recombinant Human PAK3 Protein (His Tag)(Active) 50ug
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