89-7745-13　Recombinant Human TLK2/PKU-ALPHA Protein 50ug　PKSH030362

特徴

• 背景：Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

仕様

• サイズ：50ug
• 種由来：Human
• 発現宿主：Baculovirus-Insect Cells
• 純度：> 95 % as determined by reducing SDS-PAGE.
• エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
• アクセッションＮｏ．：Q86UE8-1
• アミノ酸配列：Leu 397-Asn772
• 遺伝子構造：A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
• 別名（遺伝子名）：HsHPK;PKU-ALPHA
• 分子量：43.6 kDa
• 組成：Supplied as sterile 20mM Tris; 500mM NaCl; 3mM DTT; 10% glycerol; pH 8.0
• 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37181-Elabscience-PKSH030362.pdf
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