89-7745-06 ［取扱停止］Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)(Active) 20ug PKSH030359
[Elabscience]
特徴
- 背景：DCAMKL1; also known as DCLK1; is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains; which bind microtubules and regulate microtubule polymerization; a C-terminal serine/threonine protein kinase domain; which shows substantial homology to Ca2+/calmodulin-dependent protein kinase; and a serine/proline-rich domain in between the doublecortin and the protein kinase domains; which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes; including neuronal migration; retrograde transport; neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 84 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O15075-1
- タグ種類：N-His & GST
- アミノ酸配列：Met 1-Val 705
- 遺伝子構造：A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：The specific activity was determined to be 6.1 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate.
- 別名（遺伝子名）：CL1;CLICK1;DCAMKL1;DCDC3A;DCLK
- 分子量：106 kDa
- 組成：Supplied as sterile 20mM Tris; 500mM NaCl; pH 7.4; 10% gly; 0.5mM PMSF
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37179-Elabscience-PKSH030359.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7745-07
Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)(Active) 50ug
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89-7745-06
Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)(Active) 20ug
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