89-7744-93 ［取扱停止］Recombinant Human STK10/LOK Protein (His Tag)(Active) 20ug PKSH030352
[Elabscience]
特徴
- 背景：Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：E.coli
- 純度：> 95 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：Please contact us for more information.
- アクセッションＮｏ．：NP_005981.3
- タグ種類：N-His
- アミノ酸配列：Arg 18-Glu 317
- 遺伝子構造：A DNA sequence encoding the human STK10 (NP_005981.3) (Arg 18-Glu 317) was expressed, with a polyhistide tag at the N-terminus.
- 活性：The specific activity was determined to be 1353 nmol/min/mg using synthetic AXLtide peptide (KKSRGDYMTMQIG) as substrate.
- 別名（遺伝子名）：LOK;PRO2729
- 分子量：36 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105347-Elabscience-PKSH030352.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7744-94
Recombinant Human STK10/LOK Protein (His Tag)(Active) 50ug
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89-7744-93
Recombinant Human STK10/LOK Protein (His Tag)(Active) 20ug
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