89-7744-92 Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)(Active) 50ug PKSH030350
[Elabscience]
特徴
- 背景：G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 93 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：P43250-2
- タグ種類：N-His & GST
- アミノ酸配列：Met 1-Arg 589
- 遺伝子構造：A DNA sequence encoding the human GRK6 isofrom B (P43250-2) (Met 1-Arg 589) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：The specific activity was determined to be 7 nmol/min/mg using casein as substrate.
- 別名（遺伝子名）：GPRK6
- 分子量：95.1 kDa
- 組成：Supplied as sterile 20mM Tris, 500mM NaCl, 2mM GSH, 0.5mM PMSF, pH 7.4
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-105346-Elabscience-PKSH030350.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7744-91
Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)(Active) 20ug
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89-7744-92
Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)(Active) 50ug
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