89-7744-85 ［取扱停止］Recombinant Human MAP4K2/GC Kinase Protein (His & GST Tag) 20ug PKSH030347
[Elabscience]
特徴
- 背景：Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein and MAP4K2, is a cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 87 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：AAH47865.1
- タグ種類：N-His & GST
- アミノ酸配列：Met 1-Tyr 812
- 遺伝子構造：A DNA sequence encoding the human MAP4K2 (AAH47865.1) (Met 1-Tyr 812) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 別名（遺伝子名）：BL44;GCK;MAP4K2;RAB8IP
- 分子量：119 kDa
- 組成：Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.0
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37172-Elabscience-PKSH030347.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7744-86
Recombinant Human MAP4K2/GC Kinase Protein (His & GST Tag) 50ug
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89-7744-85
Recombinant Human MAP4K2/GC Kinase Protein (His & GST Tag) 20ug
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