89-7744-84 Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)(Active) 50ug PKSH030346
[Elabscience]
特徴
- 背景：The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins; regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
仕様
- サイズ：50ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 80 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug as determined by the LAL method.
- アクセッションＮｏ．：O75460-1
- タグ種類：N-His & GST
- アミノ酸配列：Pro 465-Leu 977
- 遺伝子構造：A DNA sequence encoding the human ERN1 isoform 1 (O75460-1) cytoplasmic domain (Pro 465-Leu 977) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 活性：1.Kinase activity untested 2. The specific activity was determined to be 5 nmol/min/mg using MBP as substrate
- 別名（遺伝子名）：hIRE1p;IRE1;IRE1a;IRE1P
- 分子量：86 kDa
- 組成：Supplied as sterile 20mM Tris; 500mM NaCl; 10% gly; pH 7.4
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37171-Elabscience-PKSH030346.pdf
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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89-7744-84
Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)(Active) 50ug
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89-7744-83
Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)(Active) 20ug
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