89-7744-76　Recombinant Human RET Kinase Protein (aa 658-1114, His & GST Tag)(Active) 50ug　PKSH030342

特徴

• 背景：RET proto-oncogene; also known as RET; is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily; tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation; neuronal navigation; cell migration; and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand; triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary); promotes survival and down regulates growth hormone (GH) production; but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer; hirschsprung disease type 1; medullary thyroid carcinoma; multiple neoplasia type 2B; susceptibility to pheochromocytoma; multiple neoplasia type 2A; thyroid papillary carcinoma and congenital central hypoventilation syndrome.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy