89-7744-66 ［取扱停止］Recombinant Human CSNK1G2 Protein (His Tag)(Active) 20ug PKSH030337
[Elabscience]
特徴
- 背景：Casein kinase I gamma 2 isoform (CSNK1G2); a member of the large casein kinase I (CKI) subfamily; protein kinase superfamily. It may affect the development of brain; and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha; beta; gamma; and delta). Dishevelled (Dsh); another positive component of the Wnt pathway; becomes phosphorylated in response to Wnt signals. All the CKI isoforms; with the exception of gamma; increase the phosphorylation of Dsh in vivo. Casein kinase 1 gamma (CK1gamma; or CSNK1G) is associated with the cell membrane and binds to LRP. CK1gamma was found to be needed for Wnt signaling through Wnt receptor LRP. CSNK1G2 inhibits Smad3-mediated TGF-beta responses including induction of target genes and cell growth arrest; and this inhibition is dependent on CSNK1G2 kinase activity. The overexpression of CSNK1G2 in human cancers; may act as an oncoprotein during tumorigenesis. In addition; as an MTA1s-binding protein; CSNK1G2 could further potentiate the estrogen receptor (ER) corepressive function of MTA1s.
仕様
- サイズ：20ug
- 種由来：Human
- 発現宿主：Baculovirus-Insect Cells
- 純度：> 80 % as determined by reducing SDS-PAGE.
- エンドトキシン濃度：< 1.0 EU per ug of the protein as determined by the LAL method.
- アクセッションＮｏ．：P78368-1
- タグ種類：N-His
- アミノ酸配列：Met 18-Lys 415
- 遺伝子構造：A DNA sequence encoding the mature form of human CSNK1G2 (P78368-1) (Met 18-Lys 415) was expressed; with a polyhistidine tag at the N-terminus.
- 活性：The specific activity was determined to be 13 nmol/min/mg using casein as substrate.
- 別名（遺伝子名）：Casein kinase I isoform gamma-2; CK1G2; CSNK1G2
- 分子量：47.8 kDa
- 組成：Supplied as sterile 20mM Tris; 500mM NaCl; 10% gly; 1mM DTT; pH 8.0
- 保存条件：Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
- メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-37163-Elabscience-PKSH030337.pdf
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| 商品イメージ | アズワン品番 商品名 |
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89-7744-67
Recombinant Human CSNK1G2 Protein (His Tag)(Active) 50ug
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89-7744-66
Recombinant Human CSNK1G2 Protein (His Tag)(Active) 20ug
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