89-7605-03　［取扱停止］Tip60 Polyclonal Antibody 60uL　E-AB-36503

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling, Immunology, Microbiology
• 背景：Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

仕様

• 抗体タイプ：ポリクローナル 抗体
• アプリケーション：WB,ELISA
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1mg/mL
• 抗原：Synthesized peptide derived from human Tip60 Polyclonal
• 緩衝液：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-2000, ELISA 1：10000-20000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-42512-Elabscience-E-AB-36503.pdf
• サイズ：60uL
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