特徴
- 主な研究分野例:Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
- 背景:Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
仕様
- 抗体タイプ:ポリクローナル 抗体
- アプリケーション:WB,IHC-p,ELISA
- 交差性:Human
- 宿主:Rabbit
- アイソタイプ:IgG
- 濃度:1 mg/mL
- 抗原:Synthesized peptide derived from the Internal region of human Stat1
- 緩衝液:PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
- 精製方法:Affinity purification
- 希釈倍率:WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
- 標識:Unconjugated
- クローナリティ:Polyclonal
- メーカーマニュアルリンク:https://www.elabscience.com/viewpdf-29304-Elabscience-E-AB-32979.pdf
- サイズ:120uL
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL:06-6447-8641
- FAX:06-6447-8642
- E-mail:[email protected]
商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7600-61
Stat1 Polyclonal Antibody 20uL
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89-7600-63
Stat1 Polyclonal Antibody 120uL
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89-7600-64
Stat1 Polyclonal Antibody 200uL
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89-7600-62
Stat1 Polyclonal Antibody 60uL
|
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