89-7598-41　［取扱停止］p53 Polyclonal Antibody 120uL　E-AB-32472

特徴

• 主な研究分野例：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
• 背景：Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

仕様

• 抗体タイプ：ポリクローナル 抗体
• アプリケーション：WB,ELISA
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1mg/mL
• 抗原：Synthesized peptide derived from human p53 around the non-phosphorylation site of Thr18.
• 緩衝液：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, ELISA 1：20000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-28797-Elabscience-E-AB-32472.pdf
• サイズ：120uL
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