特徴
- 主な研究分野例:Cancer, Cardiovascular, Epigenetics and Nuclear Signaling
- 背景:Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
仕様
- 抗体タイプ:ポリクローナル 抗体
- アプリケーション:WB,IHC-p,IF,ELISA
- 交差性:Human,Mouse,Rat
- 宿主:Rabbit
- アイソタイプ:IgG
- 濃度:1mg/mL
- 抗原:Synthesized peptide derived from the Internal region of human Hexim1
- 緩衝液:PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
- 精製方法:Affinity purification
- 希釈倍率:WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
- 標識:Unconjugated
- クローナリティ:Polyclonal
- メーカーマニュアルリンク:https://www.elabscience.com/viewpdf-27984-Elabscience-E-AB-31659.pdf
- サイズ:60uL
- この商品は法規制を確認しておりません。(法規制によって販売できない場合もございます)
- 【試薬に関するお問合せ】
- アズワン株式会社 試薬・プロセス材料グループ
- TEL:06-6447-8641
- FAX:06-6447-8642
- E-mail:[email protected]
商品のバリエーション (サイズ違い・スペック違い・オプション品など)
| 商品イメージ | アズワン品番 商品名 |
|---|---|
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89-7595-46
Hexim1 Polyclonal Antibody 120uL
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89-7595-47
Hexim1 Polyclonal Antibody 200uL
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89-7595-45
Hexim1 Polyclonal Antibody 60uL
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89-7595-44
Hexim1 Polyclonal Antibody 20uL
|
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