89-7591-45　［取扱停止］Chk1 Polyclonal Antibody 60uL　E-AB-30911

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling
• 背景：Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee 1 in vitro, providing evidence that the hyperphosphorylated form of Wee 1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.

仕様

• 抗体タイプ：ポリクローナル 抗体
• アプリケーション：WB,ELISA
• 交差性：Human
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1mg/mL
• 抗原：Synthesized peptide derived from human Chk1 around the non-phosphorylation site of S280.
• 緩衝液：PBS with 0.02％ sodium azide,0.5％ BSA and 50％ glycerol pH 7.4.
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, ELISA 1：10000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-27236-Elabscience-E-AB-30911.pdf
• サイズ：60uL
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