89-7585-08　［取扱停止］HDAC1 Monoclonal Antibody 120uL　E-AB-22208

特徴

• 主な研究分野例：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells
• 背景：Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

仕様

• 抗体タイプ：モノクローナル 抗体
• アプリケーション：IHC-p
• 交差性：Human,Mouse,Rat
• 宿主：Mouse
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthetic Peptide of HDAC1
• 緩衝液：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
• 精製方法：Protein A purification
• 希釈倍率：IHC 1：100-200
• 標識：Unconjugated
• クローナリティ：Monoclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-42056-Elabscience-E-AB-22208.pdf
• サイズ：120uL
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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