89-7579-95　［取扱停止］NFkB p65 Monoclonal Antibody 200uL　E-AB-22066

特徴

• 主な研究分野例：Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Neuroscience, Signal Transduction
• 背景：Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel,are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

仕様

• 抗体タイプ：モノクローナル 抗体
• アプリケーション：WB,IHC-p,IF,IP
• 交差性：Human,Mouse,Rat
• 宿主：Mouse
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Recombinant Protein
• 緩衝液：PBS with 0.02％ sodium azide and 50％ glycerol pH 7.4.
• 精製方法：Protein A purification
• 希釈倍率：WB 1：500-2000, IHC 1：50-300, IF 1：200, IP 1：200
• 標識：Unconjugated
• クローナリティ：Monoclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-24718-Elabscience-E-AB-22066.pdf
• サイズ：200uL
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