89-7577-71　［取扱停止］Phospho-Topo IIa (Ser1525) Polyclonal Antibody 60uL　E-AB-21933

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling
• 背景：This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

仕様

• 抗体タイプ：抗リン酸化 抗体
• アプリケーション：WB,IHC-p,ELISA
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthesized peptide derived from human Topo IIa around the phosphorylation site of S1525.
• 緩衝液：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, IHC 1：100-1：300, ELISA 1：5000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-41831-Elabscience-E-AB-21933.pdf
• サイズ：60uL
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