89-7577-46　Phospho-p70 S6 kinase a (Ser418) Polyclonal Antibody 20uL　E-AB-21476

特徴

• 主な研究分野例：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
• 背景：P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

仕様

• 抗体タイプ：抗リン酸化 抗体
• アプリケーション：WB,IHC-p,IF,ELISA
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthesized peptide derived from human p70 S6 kinase a around the phosphorylation site of Ser418
• 緩衝液：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-41123-Elabscience-E-AB-21476.pdf
• サイズ：20uL
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