89-7572-40　［取扱停止］Phospho-c-Src (Tyr529) Polyclonal Antibody 200uL　E-AB-20851

特徴

• 主な研究分野例：Cancer, Epigenetics and Nuclear Signaling, Signal Transduction
• 背景：Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.

仕様

• 抗体タイプ：抗リン酸化 抗体
• アプリケーション：WB,IHC-p,ELISA
• 交差性：Human,Mouse,Rat,Monkey
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：1 mg/mL
• 抗原：Synthesized peptide derived from human c-Src around the phosphorylation site of Tyr529
• 緩衝液：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, IHC 1：100-1：300, ELISA 1：10000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-25440-Elabscience-E-AB-20851.pdf
• サイズ：200uL
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