89-7560-45　SMAD4 Polyclonal Antibody 20uL　E-AB-16957

特徴

• 主な研究分野例：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction, Stem cells
• 背景：This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

仕様

• 抗体タイプ：ポリクローナル 抗体
• アプリケーション：IHC,ELISA
• 交差性：Human,Mouse,Rat
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.5 mg/mL
• 抗原：Fusion protein of human SMAD4
• 緩衝液：PBS with 0.05％ sodium azide and 50％ glycerol, PH7.4
• 精製方法：Affinity purification
• 希釈倍率：IHC 1：50-200, ELISA 1：1000-2000
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-36352-Elabscience-E-AB-16957.pdf
• サイズ：20uL
• この商品は法規制を確認しておりません。（法規制によって販売できない場合もございます）

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