89-7451-90　［取扱停止］GP1BA Polyclonal Antibody 120uL　E-AB-11281

特徴

• 主な研究分野例：Cancer, Cardiovascular, Immunology
• 背景：Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

仕様

• 抗体タイプ：ポリクローナル 抗体
• アプリケーション：WB,IHC,ELISA
• 交差性：Human,Mouse
• 宿主：Rabbit
• アイソタイプ：IgG
• 濃度：0.8 mg/mL
• 抗原：Recombinant protein of human GP1BA
• 緩衝液：PBS with 0.05％ sodium azide and 50％ glycerol, PH7.4
• 精製方法：Affinity purification
• 希釈倍率：WB 1：500-1：2000, IHC 1：100-1：300
• 標識：Unconjugated
• クローナリティ：Polyclonal
• メーカーマニュアルリンク：https://www.elabscience.com/viewpdf-31321-Elabscience-E-AB-11281.pdf
• サイズ：120uL
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