86-7934-29 ［取扱停止］Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified) 50ug CDB-C5224
特徴
- Background：Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
- Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
- There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
- CD32 is a low affinity receptor for IgG.
- Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2.
- CD32B is expressed on B cells and myeloid dendritic cells.
- Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis.
- Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation.
- CD32B may also be a target for monoclonal antibody therapy for malignancies.
仕様
- サイズ：50ug
- Source：Cynomolgus CD32b, His Tag (CDB-C5224) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 224 (Accession # Q8SPW3-1).
- Molecule：Fc gamma RIIB / CD32b
- Species：Cynomolgus
- Tag：His Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 46 - Pro 224
- Conjugate：Unconjugated
- Accession：NP_001271060.1
- Molecular Weight：21.8 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.8 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>90% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：50ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7934-29
Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified) 50ug
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86-7934-30
Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified) 100ug
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