Background：FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma .
Also acts as a receptor for the Fc region of immunoglobulin epsilon .
Binds with intermediate affinity to both IgG2a and IgG2b .
Does not display binding to IgG1 or IgG3.
Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.
Binds with low affinity to both the a and b allotypes of IgE.
Has also been shown to bind to IgE allotype a only but not to allotype b.
Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions
仕様
サイズ：25ug
Source：Biotinylated Mouse Fc gamma RIV, His,Avitag (BLI verified) (FC4-M82E8) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Gln 203 (Accession # A0A0B4J1G0-1).
Molecule：Fc gamma RIV / CD16-2
Synonyms：Fc gamma RIV,CD16-2,Fcgr4
Species：Mouse
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gly 21 - Gln 203
Conjugate：Precision Avi
Accession：NP_653142.2
Molecular Weight：24.6 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 24.6 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
