Background：Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
CD32 is a low affinity receptor for IgG.
The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells.
CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIMbearing receptors may also be coexpressed and coengaged by specific ligands.
CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production.
The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
仕様
サイズ：25ug
Source：Biotinylated Cynomolgus CD32a, His,Avitag (CDA-C82E5) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Pro 208 (Accession # Q8SPW4-1).
Molecule：Fc gamma RIIA / CD32a
Synonyms：CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2
Species：Cynomolgus
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gln 28 - Pro 208
Conjugate：Precision Avi
Accession：NP_001270598.1
Molecular Weight：23.9 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 23.9 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
