Background：Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
CD32 is a low affinity receptor for IgG.
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2.
CD32B is expressed on B cells and myeloid dendritic cells.
Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis.
Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation.
CD32B may also be a target for monoclonal antibody therapy for malignancies.
仕様
サイズ：25ug
Source：Biotinylated Human CD32b/c, Avitag,His Tag (CDB-H82E0) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994-1). In the region Ala 46 - Pro 217, the AA sequence of Fc gamma RIIB and Fc gamma RIIC are homologus.
Characteristics：This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 23.0 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
