Background：FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer.
Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk.
FCGRT possible role in transfer of immunoglobulin G from mother to fetus.
Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
仕様
サイズ：25ug
Source：MABSol Biotinylated Bovine FcRn Heterodimer Protein, His,Avitag (FCN-B82W3) is expressed from human HEK293 cells. It contains AA Ala 24 - Pro 298 (FCGRT) & Ile 21 - Leu 118 (B2M) (Accession # Q3T119-1 (FCGRT) & P01888-1 (B2M)).
Molecule：FcRn (FCGRT & B2M)
Synonyms：FcRn,FCGRT & B2M
Species：Bovine
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Ala 24 - Pro 298 (FCGRT) & Ile 21 - Leu 118 (B2M)
Conjugate：Precision Avi
Accession：NP_788830.1 (FCGRT) & NP_776318.1 (B2M)
Molecular Weight：34.5 kDa (FCGRT) and 11.6 kDa (B2M)
Characteristics：Biotinylated Bovine FcRn Heterodimer Protein, His,Avitag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.5 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag) and subunit B2M contains no tag. The reducing (R) protein migrates as 35-38 kDa (FCGRT) and 12 kDa (B2M) respectively due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
