86-7933-95　［取扱停止］Human CD23 / Fc epsilon RII Protein, His Tag (MALS verified) 100ug　CD3-H5249

特徴

• Background：Cluster of differentiation 23 (CD23) is also known as Low affinity immunoglobulin epsilon Fc receptor (FCER2), C-type lectin domain family 4 member J (CLEC4J), Fc-epsilon-RII (FcεRII), Immunoglobulin E-binding factor (IGEBF), is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.
• Unlike many of the antibody receptors, CD23 is a C-type lectin.
• It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets.There are two forms of CD23: CD23a and CD23b.
• CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages.
• CD23 is known to have role of transportation in antibody feedback regulation.
• Antigen that enters the blood stream is captured by antigen specific IgE antibodies.
• The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen.
• The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells.
• The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response.
• In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative).