Background：Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16.
Fc gamma RI binds IgG with high affinity and functions during early immune responses.
Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.
High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family.
CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.
仕様
サイズ：25ug
Source：Biotinylated Human CD64, His,Avitag (FCA-H82E8) is expressed from human 293 cells (HEK293). It contains AA Gln 16 - Pro 288 (Accession # P12314-1).
Molecule：Fc gamma RI / CD64
Synonyms：FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gln 16 - Pro 288
Conjugate：Precision Avi
Accession：AAH32634.1
Molecular Weight：34.2 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 34.2 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
