86-7933-73 ［取扱停止］Human Fc gamma RIIB/C / CD32b/c Protein, His Tag (SPR & BLI & MALS verified) 100ug CDB-H5228
特徴
- Background：Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
- Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
- There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
- CD32 is a low affinity receptor for IgG.
- Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2.
- CD32B is expressed on B cells and myeloid dendritic cells.
- Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis.
- Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation.
- CD32B may also be a target for monoclonal antibody therapy for malignancies.
仕様
- サイズ：100ug
- Source：Human CD32b/c, His Tag (CDB-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994-1). In the region Ala 46 - Pro 217, the AA sequence of Fc gamma RIIB and Fc gamma RIIC are homologus.
- Molecule：Fc gamma RIIB/C / CD32b/c
- Synonyms：FCGR2B/C,CD32b/c,FcRII-b/c,Fc-gamma RII-b/c,Fc-gamma-RIIb/c,CD32,FCG2,IGFR2,CDw32
- Species：Human
- Tag：His Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 46 - Pro 217
- Conjugate：Unconjugated
- Accession：NP_001002273.1
- Molecular Weight：20.4 kDa
- Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 25-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：100ug*1
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商品のバリエーション （サイズ違い・スペック違い・オプション品など）
| 商品イメージ | アズワン品番 商品名 |
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86-7933-73
Human Fc gamma RIIB/C / CD32b/c Protein, His Tag (SPR & BLI & MALS verified) 100ug
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86-7933-74
Human Fc gamma RIIB/C / CD32b/c Protein, His Tag (SPR & BLI & MALS verified) 50ug
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