Background：FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer.
Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk.
FCGRT possible role in transfer of immunoglobulin G from mother to fetus.
Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
仕様
サイズ：25ug
Source：MABSol Biotinylated Mouse FcRn Heterodimer Protein, Avitag,His Tag&Twin-Strep Tag (FCM-M82W6) is expressed from human HEK293 cells. It contains AA Ser 22 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q61559-1 (FCGRT) & P01887-1 (B2M)).
Molecule：FcRn (FCGRT & B2M)
Synonyms：FcRn,FCGRT & B2M
Species：Mouse
Tag：His Tag & Strep Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Ser 22 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
Conjugate：Precision Avi
Accession：NP_034319.2 (FCGRT) & NP_033865.2 (B2M)
Molecular Weight：34.7 kDa (FCGRT), 14.7 kDa (B2M)
Characteristics：Biotinylated Mouse FcRn Heterodimer Protein, Avitag,His Tag&Twin-Strep Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.7 kDa (FCGRT) and 14.7 kDa (B2M). Subunit FCGRT is fused with an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag and subunit Beta-2 microglobulin (B2M) is fused with Twin-Strep tag at the C-terminus. The reducing (R) protein migrates as 45-50 kDa (FCGRT) and 15 kDa (B2M) respectively due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
