86-7933-64 ［取扱停止］Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, Avitag,His Tag&Strep II Tag (SPR & BLI & MALS verified) 200ug FCM-H82W4
特徴
- Background：FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer.
- Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk.
- FCGRT possible role in transfer of immunoglobulin G from mother to fetus.
- Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
仕様
- サイズ：200ug
- Source：Biotinylated Human FCGRT&B2M Heterodimer Protein, Avitag,His Tag&Strep II Tag (FCM-H82W4) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M)).
- Molecule：FcRn (FCGRT & B2M)
- Synonyms：FcRn,FCGRT & B2M
- Species：Human
- Tag：His Tag & Strep Tag & Avi Tag
- Expression Systems：HEK293
- Expression Rigeion：Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
- Conjugate：Precision Avi
- Accession：NP_004098.1 (FCGRT) & NP_004039.1 (B2M)
- Molecular Weight：34.1 kDa (FCGRT) & 13.1 kDa (B2M)
- Characteristics：Biotinylated Human FCGRT&B2M Heterodimer Protein, Avitag,His Tag&Strep II Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 13.1 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag) and subunit Beta-2 microglobulin (B2M) is fused with Strep II-tag at the C-terminus. The reducing (R) protein migrates as 38 kDa (FCGRT) and 14 kDa (B2M) respectively due to glycosylation.
- Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
- Purity：>95% as determined by SDS-PAGE.
- Buffer：PBS, pH7.4
- Package Size：200ug*1
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