Background：CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b).
These receptors bind to the Fc portion of IgG antibodies.
CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.
CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha.
CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes.
Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
仕様
サイズ：25ug
Source：Biotinylated Human CD16a (V176), Avitag,His Tag (SPR & BLI verified) (CDA-H82E9) is expressed from human 293 cells (HEK293). It contains AA Gly 17 - Gln 208 (Accession # P08637-1).
Molecule：Fc gamma RIIIA / CD16a
Synonyms：FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Gly 17 - Gln 208
Conjugate：Precision Avi
Molecular Weight：25.5 kDa
Characteristics：This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 25.5 kDa. The protein migrates as 36-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
