Background：B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions.
B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function.
Recently, B7-H7 has been identified as a specific ligand for human CD28H.
The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway.
The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
仕様
サイズ：25ug
Source：Biotinylated Human B7-H7, His,Avitag (B77-H82E3) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Asn 344 (Accession # Q9UM44-1).
Molecule：B7-H7
Synonyms：B7-H7,HHLA2,B7 Homolog 7
Species：Human
Tag：His Tag & Avi Tag
Expression Systems：HEK293
Expression Rigeion：Ile 23 - Asn 344
Conjugate：Precision Avi
Accession：NP_009003.1
Molecular Weight：40.7 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag). The protein has a calculated MW of 40.7 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
