Background：Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
TNFRSF-8 is expressed by activated, but not by resting, T and B cells.
Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15.
CD30 is the receptor for TNFSF8/CD30L.
CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B.
TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts.
TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
仕様
サイズ：100ug
Source：Canine CD30, His Tag (CD0-C52H4) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Gly 284 (Accession # XP_013966925.1).
Molecule：CD30
Synonyms：TNFRSF8,CD30,D1S166E,Ki-1
Species：Canine
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Met 1 - Gly 284
Conjugate：Unconjugated
Accession：XP_013966925.1
Molecular Weight：31.5 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.5 kDa. The protein migrates as 45-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
