Background：Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.
Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus.
Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
仕様
サイズ：100ug
Source：Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (IT3-H52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3) (Accession # NP_002201.1 (ITGAV) & NP_000203.2 (ITGB3)).
Molecule：Integrin alpha V beta 3
Synonyms：Integrin alpha V beta 3,ITGAV&ITGB3
Species：Human
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3)
Characteristics：Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 112.9 kDa (ITGAV) and 81.8 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-150 kDa (ITGAV) and 90-100 kDa (ITGB3) respectively due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
