Background：V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family.
VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains.
The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs).
VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity.
VTCN1 involved in promoting epithelial cell transformation.
仕様
サイズ：100ug
Source：Mouse B7-H4, His Tag (B74-M52H9) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gly 257 (Accession # Q7TSP5-1).
Molecule：B7-H4
Synonyms：B7-H4,VTCN1,B7S1,B7h.5
Species：Mouse
Tag：His Tag
Expression Systems：HEK293
Expression Rigeion：Leu 25 - Gly 257
Conjugate：Unconjugated
Accession：NP_848709.2
Molecular Weight：27.6 kDa
Characteristics：This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.6 kDa. The protein migrates as 45-66kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level：Less than 1.0 EU per ug by the LAL method.
